| 车次 | 出发站 | 开车时间 | 到达站 | 到达时间 |
| K593 | 开封 | 05:38 | 阜阳 | 09:25 |
| K596 | 开封 | 05:38 | 阜阳 | 09:25 |
| K132 | 开封 | 07:43 | 阜阳 | 11:56 |
| K133 | 开封 | 07:43 | 阜阳 | 11:56 |
| K742 | 开封 | 13:36 | 阜阳 | 17:22 |
| K743 | 开封 | 13:36 | 阜阳 | 17:22 |
| G859 | 开封北 | 14:22 | 阜阳西 | 16:10 |
| G862 | 开封北 | 14:22 | 阜阳西 | 16:10 |
| K1237 | 开封 | 15:20 | 阜阳 | 19:19 |
| K1240 | 开封 | 15:20 | 阜阳 | 19:19 |
| K29 | 开封 | 16:26 | 阜阳 | 20:13 |
| K32 | 开封 | 16:26 | 阜阳 | 20:13 |
| G1877 | 开封北 | 19:06 | 阜阳西 | 20:47 |
| G1880 | 开封北 | 19:06 | 阜阳西 | 20:47 |
| T325 | 开封 | 19:30 | 阜阳 | 23:37 |
| T328 | 开封 | 19:30 | 阜阳 | 23:37 |
| Z146 | 开封 | 20:51 | 阜阳 | 23:28 |
| Z147 | 开封 | 20:51 | 阜阳 | 23:28 |
| K605 | 开封 | 22:11 | 阜阳 | 02:10 |
| K608 | 开封 | 22:11 | 阜阳 | 02:10 |
| K60 | 开封 | 23:16 | 阜阳 | 03:29 |
| K61 | 开封 | 23:16 | 阜阳 | 03:29 |
| K2275 | 开封 | 23:58 | 阜阳 | 03:42 |
| K2278 | 开封 | 23:58 | 阜阳 | 03:42 |